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Effect of DEAE Sephadex on Liver Vitamin A of Lactating Rats and Their Offspring

ARS, Animal Science Research Division, U.S. Department of Agriculture, Beltsville, Maryland 20705

The effect of feeding DEAE Sephadex or cholestyramine, anion exchangers which bind bile acids and enhance their fecal excretion, was studied in pregnant and lactating rats and the postpartum changes in liver vitamin A of the mothers and pups were followed. DEAE Sephadex fed in a 15% fat diet to pregnant and lactating rats reduced liver vitamin A concentration by 27 to 32% in the mothers and their pups. A similar reduction occurred when cholestyramine was fed in an 0.9% fat diet. However, feeding DEAE Sephadex in the 0.9% fat diet to pregnant rats had less effect on liver vitamin A concentration in the mothers and their offspring. When weanling male rats were fed DEAE Sephadex in the 0.9% fat diet, liver vitamin A concentration was reduced by 29%.

KEY WORDS: • DEAE Sephadex • vitamin A

Manuscript received 25 February 1972.