Journal of Nutrition

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 103 No. 1 January 1973, pp. 36-42
Copyright © 1973 by American Society for Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dryden, L. P.
Right arrow Articles by Weyant, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dryden, L. P.
Right arrow Articles by Weyant, J.

Influence of Feeding DEAE Sephadex on Growth, Lactation and Lipid Utilization in the Rat1

L. P. Dryden, J. Bitman, T. R. Wrenn and J. Weyant

United States Department of Agriculture, ARS, Animal Science Research Division, Beltsville, Maryland 20705

The effects on the rat of incorporating in the ration DEAE Sephadex, a bile acid sequestrant which is not absorbed from or degraded in the intestinal tract, were studied. Diets containing 0.9% or 15% fat, as well as a hypercholesterolemic diet, were employed. The fecal fat (ether extract) was doubled on the 0.9% fat diet and the hypercholesterolemic diet and increased by 4 to 5 times on the 15% fat diet. The serum cholesterol levels were not affected on the normal diets but DEAE Sephadex prevented the elevated levels observed on the hypercholesterolemic control diet. In none of the diets did DEAE Sephadex affect 4-week weight gains of weanling young significantly but weight gain per calorie consumed was lowered in males fed the 15% fat ration, presumably due to a loss of dietary calories in the feces. The body weights of young of mothers fed DEAE Sephadex in the 0.9% fat ration were depressed about 7 to 8% by 15 days of age. The young from control mothers contained about 25% more fat and about 10% more nonfat solids in their bodies.

KEY WORDS: • DEAE Sephadex • bile acid sequestrants • lactation in rat • fat absorption

1 Preliminary results of this investigation were presented at the 55th Annual Meeting of the Federation of American Societies for Experimental Biology, Chicago, Ill., 1971. (Federation Proc. 30: 344, abstr. 853).

Manuscript received 8 March 1972.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]