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Selenium Retention in Tissues and Sperm of Rats Fed Torula Yeast Diet¹

Bioenergetics Division, U. S. Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital, Denver, Colorado 80240

The tissue retention of a submicrogram dose of ⁷⁵SeO₂^2- was studied over a 10-week period. Twenty male and 10 female weanling rats were fed a Torula yeast diet with no selenium supplementation. Thirty days after the diet was begun, 2 µCi of ⁷⁵Se as H₂SeO₂ (206 Ci/g) was injected into each animal intraperitoneally. Groups of animals were killed at 3 hours, 1 day, 1, 2, 3, 4, 6, 8 and 10 weeks. The ⁷⁵Se content was determined for 16 tissues on a percentage of dose per gram basis. The female rats showed a consistently higher retention in all tissues except the brain, which was the same in both sexes, and the reproductive organs. Most tissues except the brain, thymus, and reproductive organs showed a decline in activity from day 1. The brain reached its activity peak at 2 to 3 weeks, and the thymus at 1 to 2 weeks. The testis showed a peak at 2 weeks followed by a peak in the epididymis at 4 weeks. The ovary and uterus showed steadily declining ⁷⁵Se contents. The testis-epididymis complex contained 41.8% of the total body ⁷⁵Se at 3 weeks. Autoradiography was performed on epididymal sperm and the ⁷⁵Se was seen to be localized to the midpiece of the sperm.

KEY WORDS: • selenium • Torula yeast • sperm

¹ Presented in part at the 56th Annual Meeting of FASEB, Atlantic City, N. J., April 11, 1972. Federation Proc. 31: 692, 1972 (abstr.).

² To whom reprint requests should be sent.

Manuscript received 12 June 1972.

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