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Studies on Riboflavin Deficiency in Tetrahymena pyriformis¹

Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706

Several flavin enzymes are located in the microbodies. One of these enzymes, lactate oxidase, was studied using the ciliated protozoan, Tetrahymena pyriformis, grown in riboflavin-deficient medium as a model system. During riboflavin deficiency, lactate oxidase activity was low and did not increase when culture conditions were altered. Lipid glyconeogenesis was strikingly reduced and fatty acid patterns included more short-chain and, perhaps, hydroxy fatty acids. Survival of the organism during near anaerobic conditions was limited.

KEY WORDS: • riboflavin • lactate oxidase • Tetrahymena • glycogen metabolism

¹ Supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison, and by U. S. Public Health Service Grant no. GM 14033.

Manuscript received 17 February 1972.