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Metabolism of L-Methionine-³⁵S in Zinc-deficient Rats

Biochemistry Research Laboratory, Veterans Administration Hospital, Baltimore, Maryland 21218 and Department of Pharmacology, School of Medicine, University of Louisville, Louisville, Kentucky 40202

The effect of zinc deficiency on metabolism of L-methionine-³⁵S was studied in young rats. Results indicate that urinary excretion of ³⁵S in zinc-deficient rats was significantly greater than in zinc-supplemented rats. In contrast, the uptake of ³⁵S in the skin-hair of zinc-deficient rats was considerably lower than control rats. No significant differences were observed in the protein radioactivity of the liver, kidney, pancreas, testes, and muscle between the two groups. However, zinc deficiency drastically reduced the amount of L-methionine-³⁵S and DL-methionine-2-¹⁴C incorporated into skin proteins.

KEY WORDS: • zinc deficiency • methionine-³⁵S

Manuscript received 28 January 1972.