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Absorbability by Rats of Compounds Containing from One to Eight Ester Groups

The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239

The absorbability of the fatty acid moiety of the complete, oleate esters of alcohols containing from one to six hydroxyl groups was determined by the fat balance technique in adult rats. Similarly, the absorbability of sucrose octaoleate and sucrose monooleate was determined. The fatty acids of the compounds containing less than four ester groups, methyl oleate, ethylene glycol dioleate, glycerol trioleate, and sucrose monooleate, were almost completely absorbed. As the number of ester groups was increased — erythritol and pentaerythritol tetraoleate and xylitol pentaoleate — the absorbability decreased. The fatty acids of sorbitol hexaoleate and sucrose octaoleate were not absorbed. These differences in absorbability are related to the activity and specificity of the lipolytic enzymes in the lumen of the intestinal tract.

KEY WORDS: • esters of polyols • absorbability

Manuscript received 23 February 1972.

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