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Effect of Dietary Phosphorus on Calcium Metabolism in Intact and Parathyroidectomized Adult Rats¹

Department of Food Science, University of Illinois at Urbana-Champaign, Illinois 61801

Two levels of dietary phosphorus, 0.6% and 1.2%, were compared with respect to their effect on bone resorption and calcium metabolism in intact and parathyroidectomized (PTX) rats fed a diet containing 1.2% Ca. Intact rats fed the 1.2% P diet for 34 weeks experienced a greater loss of ⁴⁵Ca from the skeleton and of calcium, phosphorus and organic matter from the femurs. These effects were not seen in PTX animals. There was no difference in the absorption of calcium from the two diets. This study indicates that excess dietary phosphorus accelerates the rate of bone resorption in adult rats and that this effect is mediated by the parathyroid gland.

KEY WORDS: • calcium • phosphorus • aging • hyperparathyroidism

¹ Supported by funds from the Illinois Agricultural Experiment Station and by research grant AM-07052 from the National Institute of Arthritis and Metabolic Diseases.

² Present address: Department of Nutrition, School of Hygiene, University of Toronto, Toronto, Ontario.

Manuscript received 17 November 1972.

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