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Influence of Dietary and Injected Selenium on Whole-body Retention, Route of Excretion, and Tissue Retention of ⁷⁵SeO₃^2- in the Rat

Bioenergetics Division, U. S. Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital, Denver, Colorado 80240

Rats which had been fed a Torula yeast diet with selenium supplements of from 0 (basal) to 1 ppm for 35 days were injected with a tracer dose of ⁷⁵SeO₃^2-. Similar animals, all fed the basal diet, received carrier selenium in the injection at three levels (20, 50, and 200 µg). Whole-body counting was performed at frequent intervals; urine and fecal ⁷⁵Se were determined for 10 days; and the animals were killed 35 days after injection and tissue retention was determined. Increase of either dietary or carrier selenium decreased whole-body retention of the ⁷⁵Se in all cases and increased its urinary excretion except in the animals given 200 µg of carrier in which volatilization apparently occurred. Fecal excretion was about the same for all groups. Testis, brain, spleen, kidney, small intestine, eye, and thymus contained the greatest percentage of the whole-body ⁷⁵Se when the basal diet was fed. This decreased as dietary selenium was increased. Skeletal muscle and blood showed the opposite pattern. The liver had the smallest percentage of whole-body ⁷⁵Se in animals fed the basal diet. Supplementation with 0.10 ppm Se almost quadrupled it, but subsequent increases caused it to drop again.

KEY WORDS: • selenium excretion • tissue selenium • testis selenium

Manuscript received 14 January 1972.

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