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Effects of Amino Acids and Hormones on the Fractional Catabolic Rate of Albumin by the Isolated Perfused Rat Liver¹

Liver Research Group, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa

The influence of amino acids, glucagon, insulin, growth hormone, hydrocortisone and triiodothyronine on the fractional catabolic rate of albumin was studied in 28 isolated rat liver perfusions. Accelerated protein synthesis, obtained by the addition of amino acids, failed to influence the fractional catabolic rate of albumin. Glucagon, growth hormone, hydrocortisone and triiodothyronine produced no change, while insulin marginally slowed catabolism. Normal fractional catabolic rates were obtained despite a low perfusate albumin concentration.

KEY WORDS: • albumin • insulin • glucagon • growth hormone • triiodothyronine • hydrocortisone • amino acids

¹ The financial support of the Wellcome Trust, the South African Medical Research Council, the South African Atomic Energy Board and the Staff Research Fund of the University of Cape Town is gratefully acknowledged.

Manuscript received 21 October 1971.