QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Tobin, R. B. Articles by Parker, M. Search for Related Content PubMed PubMed Citation Articles by Tobin, R. B. Articles by Parker, M.

Effect of 1,3-Butamediol and Propionic Acid on Blood Ketones, Lipids and Metal Ions in Rats^1,2,

Veterans Administration Hospital and Departments of Biochemistry and Medicine, University of Nebraska College of Medicine, Omaha, Nebraska 68105

The metabolic effects of feeding butanediol (BD) and propionate to rats are presented. The weight gain of animals fed either BD or propionate was less than controls while food efficiency was decreased only in the animals fed either propionate or BD plus propionate. BD decreased liver glycogen in fed rats and partially preserved glycogen in fasted animals. On the other hand, propionate slightly increased glycogen in the fed state but did not prevent the marked depletion of glycogen in fasting. Feeding either BD or propionate caused decrease of blood glucose, lactate and pyruvate, and decrease of adipose tissue weight. Propionate and BD plus propionate decreased triglycerides in blood and BD plus propionate increased fatty acids in blood. Although BD feeding markedly increased acetoacetate and ß-hydroxybutyrate in blood and in urine, propionate feeding decreased blood and urine ketones. Moreover, propionate plus BD gave blood ketones no different from BD alone and caused even greater urinary ketone excretion than BD alone. Thus, propionate does not alleviate BD-induced ketosis as would be expected. The changes which occurred in serum and liver cations and electrolytes are best related to excretion of strong organic acids as salts. The modification of BD effects on metabolism produced by propionate is discussed in relation to known interrelated metabolic pathways.

KEY WORDS: • Propionic acid • 1,3-butanediol • ketones • lipids • metal ions • glycogen • liver • kidney

¹ Supported by Celanese Chemical Company, Veterans Administration and NIH Grant no. 13,732.

² A preliminary report of this work was presented at the 1971 Midwest Regional Meeting of the American Chemical Society, St. Louis, Missouri.

Manuscript received 24 January 1972.