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The {alpha}-Macrofetoprotein Response to an Inflammatory Stimulus in Fasted Rats1

Henry E. Weimer, Dorothy M. Roberts and Jean C. Comb

Department of Medical Microbiology and Immunology, UCLA Medical School, Los Angeles, California 90024

The effects of fasting on the response of the {alpha}-macrofetoprotein ({alpha}-MFP), albumin, and seromucoid fractions of serum to an inflammatory challenge (subcutaneous injection of turpentine) were studied in adult male Sprague-Dawley rats. Significant differences in response to the phlogogen were found in {alpha}-MFP levels between the fasted and 300-g fed and the 400-g fed groups, an observation which may be due to dosage/body weight relationships. Seromucoid values were significantly increased in all challenged groups. The response of the 400-g fed rats was significantly greater than the 300-g fed animals. Albumin concentrations were severely depressed in all groups injected with turpentine. The decrease in the concentration of albumin attributed to the inflammatory stimulus was reduced by fasting. Fasting per se caused significant decreases in the albumin and seromucoid fractions. The conclusion was drawn that the response of the {alpha}-MFP and seromucoid fractions to a phlogogenic stimulus is of such magnitude as to be unaffected by acute starvation.

KEY WORDS: • embryonic serum protein • nutritional stress • albumin • seromucoid

1 Supported by Public Health Service Research Grant no. AM-08717 from the Arthritis and Metabolic Disease Institute of the National Institutes of Health.

Manuscript received 11 November 1971.




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