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Influence of Protein Deficiency on 19S Antibody-forming Cells in Rats and Mice

Department of Pathology, All-India Institute of Medical Sciences, New Delhi-16, India

Influence of protein deficiency on immune response to sheep red blood cells was investigated in rats and mice with Jerne's plaque-forming cell technique. Protein deficiency resulted in a reduction in the number of antibody-producing cells consequent upon a prolongation of cell generation time in rats. Injection of syngeneic thymocytes brings about better improvement in the immune response of the X-radiated protein-deficient mice as compared to the controls. It is suggested that depressed immunity in malnutrition may be partly due to a disturbance in thymic function.

KEY WORDS: • protein deficiency • antibodies

Manuscript received 29 December 1971.

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