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Taurine and Isethionic Acid: Distribution and Interconversion in the Rat¹

Department of Pharmacology, University of Arizona College of Medicine, Tucson, Arizona 85724

A colorimetric assay combined with a reverse isotopic dilution procedure has been used to measure taurine levels in certain rat organs. The distribution and metabolism of [1,2-¹⁴C]taurine and [G-³H]isethionic acid (ISA) have been studied in rats. A low conversion of taurine to ISA is seen in all tissues examined, but no evidence has been obtained for the reverse reaction. [G-³H]ISA undergoes extensive metabolism in the course of distribution. The highest concentration of activity from both substances is found in the heart, maximum activity being reached in 3 days for ISA and 4 days for taurine.

KEY WORDS: • taurine • isethionic acid

¹ Supported by U. S. Public Health Service Grant no. HE 13636.

Manuscript received 18 November 1971.

This article has been cited by other articles:

				R. Huxtable and R. Bressler Taurine Concentrations in Congestive Heart Failure Science, June 14, 1974; 184(4142): 1187 - 1188. [Abstract] [PDF]