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Effect of Age on Gastrointestinal Absorption (Fe, Sr, Pb) in the Rat^{1, 2,}

Departments of Pediatrics and Radiation Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

Gastrointestinal absorption of Fe, Sr, and Pb was studied as a function of age in the rat by means of isotopic labels. Iron-59 absorption was determined by whole body counting, ³⁵Sr and ²¹²Pb absorption by counting gut contents 8 hours after administration of the respective isotopes. Young animals absorb most of the administered dose of all three isotopes. At about the time of weaning absorption abruptly drops to the low level characteristic of the adult. The similarity of the age-absorption curves for Fe, Sr, and Pb suggests that a common maturation process is involved. With respect to Fe, the rate of maturation of the absorptive process can be influenced by the plane of nutrition at those ages when the transition from the infantile to the adult pattern is occurring, but not at earlier or later ages. Cortisone administration has no effect.

KEY WORDS: • gastrointestinal • absorption • iron • strontium • lead • age

¹ Supported by a grant from the Nutrition Foundation, an NIH Research Career Award (G.B.F.), and the U. S. Atomic Energy Project at the University of Rochester (Report No. UR-3490-15).

² Presented in part at a meeting of the Food Industries Advisory Committee, Naples, Florida, January 1969.

³ Recipient of an NIH International Fellowship; present address, Universida del Valle, Cali, Colombia.

Manuscript received 11 November 1971.

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