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Journal of Nutrition Vol. 102 No. 5 May 1972, pp. 639-646
Copyright © 1972 by American Society for Nutrition
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Effect of Dietary Protein and Feeding Schedule on Hepatic Polysome Patterns in the Rat1

R. A. Symmons2, E. J. Maguire and Q. R. Rogers

Department of Physiological Sciences, School of Veterinary Medicine, University of California, Davis, California 95616

Male, albino 140 to 160 g rats were adapted to a feeding period of either 2 hours (meal-fed) or 16 hours (control-fed) per day and fed 0, 6, 15, 30 or 75% casein. Meal-fed (MF) rats were adapted about 2 weeks and controlfed (CF) rats about 1 week prior to determining liver polysome pattern. MF rats were fed in the morning, while CF rats were fed during the night. Daily, diet-dependent fluctuations in polysome pattern occurred in CF rats fed low or moderate amounts of dietary protein, and fluctuations were not abolished by feeding a protein-free diet. Increased levels of protein decreased the magnitude of fluctuation. The time course of oscillation was altered by varying the level of dietary protein. Fluctuations were also observed in MF rats. In both MF and CF rats maximal aggregation occurred 4 to 8 hours after feeding was initiated. These results indicate that daily fluctuations in polysome aggregation are diet-dependent rather than circadian or light-cycle dependent, and that increased levels of dietary protein decrease normal fluctuations in hepatic polysome pattern.

KEY WORDS: • dietary protein • feeding schedule • polysome • liver protein synthesis • diet-dependent fluctuations

1 Supported in part by USPHS Research Grant AM 11066 from the National Institute of Arthritis and Metabolic Diseases.

2 Richard A. Symmons acknowledges support of NDEA Title IV Graduate Fellowship.

Manuscript received 10 September 1971.




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