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Effect of Protein, Mineral, and Vitamin Depletion and Subsequent Repletion on Lipid Content in Rat Liver

Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Furo-cho, Chikusa, Nagoya, Japan

The effect of shifting from protein-free, mineral-free, or vitamin-free diets to various types of repletion diets on the liver lipid content of rats was studied. The feeding of these three depletion diets for 14 days followed by the feeding of a repletion diet low in fat for 3 days caused an accumulation of liver lipids. However, lipid content of rats fed for 6 days was dependent on the kinds of depletion diet previously fed. The lipid accumulation in the liver was prevented by the feeding of a repletion diet high in fat or by restricting the sucrose consumption in the repletion diet containing 0.1% fat. However, the food intake of animals on day 14 of feeding the depletion diets was significantly lower than that on day 1 of feeding the repletion diet. Therefore, it is postulated that the formation of fatty liver induced by feeding a repletion diet low in fat after depletion might be due to the stimulation of lipogenesis caused by the rapid increase of carbohydrate intake of rats.

KEY WORDS: • liver lipid • depletion • repletion • protein

Manuscript received 15 October 1971.