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Interrelationships between Dietary Methionine and Cystine as Reflected by Growth, Certain Hepatic Enzymes and Liver Composition of Weanling Rats^1,2,3,

Department of Foods and Nutrition, Purdue University, Lafayette, Indiana 47907

To investigate quantitative relationships between methionine and cystine, experimental diets fed to weanling rats contained 4.8, 3.6, and 2.4 mmoles of sulfur amino acids and at each level methionine furnished 100, 75, 50 and 25% of the total and cystine 0, 25, 50 and 75%, respectively. Both the level of total sulfur-containing amino acids and the relative proportion of methionine and cystine significantly influenced food intake, weight gain, nitrogen deposition and specific activity of cystathionase in hepatic tissue but only the relative proportions of methionine and cystine altered specific activity of cystathionine synthase in liver. Interaction between level of total sulfur-containing amino acids and proportion of methionine and cystine was significant in respect to all parameters tested.

KEY WORDS: • methionine • cystine • cystathionine synthase • cystathionase

¹ From Purdue University Agricultural Experiment Station and School of Home Economics, Department of Foods and Nutrition, Lafayette, Indiana 47907. Journal paper 4576.

² The data were taken from a thesis submitted by Barbara M. Shannon in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Purdue University. The senior author was the recipient of the E. I. Raitt Fellowship from the American Home Economics Association and the research was supported in part by a David Ross Fellowship from Purdue University. Her present address is 202 Human Development Bldg., The Pennsylvania State University, University Park, Pa. 16802.

³ A preliminary report has appeared: Federation of American Societies for Experimental Biology in Chicago, Ill. Shannon, B. M., J. M. Howe and H. E. Clark 1971 Interrelationships between dietary methionine and cystine as reflected by growth and certain hepatic enzymes. Federation Proc. 30: 234 (abstr.).

Manuscript received 25 October 1971.

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