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Effect of Histidine, Histamine, and Aspirin on Sulfur-35 Metabolism in Zinc-deficient Chick Bone¹

Chemistry Division, U. S. Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital, Denver, Colorado 80240

Baby chicks were used in studies designed to determine whether or not three of the compounds (histidine, histamine, and aspirin) which correct the gross leg abnormalities associated with zinc deficiency would also correct the abnormality of sulfate metabolism in bone-forming regions, similarly associated with a deficiency of the trace element. The three compounds were supplied by the diet in the following concentrations: histidine, 1.0%; histamine, 0.2%; and aspirin, 0.75%. Following 4 or 5 weeks of these treatments in either a Zn-deficient (14 ppm) or a Zn-adequate (94 ppm) diet, the birds were orally dosed with 10 µCi of Na₃³⁵SO₄. ³⁵S content of the epiphyseal plate and the primary spongiosa from the tibia was assayed at either 6, 12, or 24 hours following isotope dosage. Zinc deficiency alone, compared to Zn-adequate chicks, resulted in reduced ³⁵S incorporation at 6 and 12 hours postdosage in the epiphyseal plate, and at 12 and 24 hours postdosage in the primary spongiosa. All three dietary additives were significantly effective in increasing ³⁵S incorporation into the epiphyseal plate in both the Zn-deficient and the Zn-adequate chicks, and into the primary spongiosa of the Zn-deficient birds. It appears that histidine, histamine, and aspirin are effective in promoting increased sulfate incorporation into bone-forming regions of the chick tibia, regardless of the zinc status of the bird.

KEY WORDS: • zinc • sulfur • zinc-sulfur interaction

¹ In conducting the research described in this report, the investigators adhered to the "Guide for Laboratory Animal Facilities and Care," as promulgated by the Committee on the Guide for Laboratory Animal Resources, National Academy of Sciences-National Research Council.

² Present address: Human Nutrition Laboratory, USDA, ARS, 2420 2nd Avenue, North, Grand Forks, N.D. 58201.

Manuscript received 30 August 1971.