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Effect of Dietary Fats on the Serum Lipoproteins in Thyroidectomized Dogs¹

Department of Medicine, Hennepin County General Hospital, (Minneapolis Medical Research Foundation), The Jay Phillips Laboratory, Mount Sinai Hospital and the University of Minnesota Medical School, Minneapolis, Minnesota 55404

The serum lipid response of eight dogs before and after surgical thyroidectomy to high fat diets with various degrees of unsaturation was studied. The serum lipids were separated into very low density, low density and high density lipoprotein categories by centrifugation and protein, cholesterol, phospholipid and triglycerides of each lipoprotein class measured. While thyroidectomy generally raises the levels of low density lipoproteins, the hypothyroid dogs demonstrate a smaller or nonexistent increase of phospholipid in response to high fat diets compared to cholesterol increases regardless of degree of saturation. Triglycerides actually in some cases decrease in the very low density and high density lipoproteins in response to high fat diets. High density lipoproteins are generally not very responsive to dietary fat increases. On the basis of these results it seems likely that there are changes in the relative proportions of lipid and protein components in circulating lipoproteins of hypothyroid dogs produced by high fat diets.

KEY WORDS: • coconut oil • lipoprotein • thyroidectomy • hypothyroid

¹ Supported by Public Health Service Grant HE 12277.

Manuscript received 2 July 1971.