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Prevention by Fluoride of Magnesium Deficiency Defects such as Growth Inhibition, Renal Abnormalities, Hyperuremia, and Hyperphosphatemia in KK Mice

Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd., Osaka (532), Japan

Experiments were performed to test the effects of certain substances on the development of magnesium deficiency defects in KK mice. Fluoride (0.06% as sodium fluoride) completely prevented all signs of magnesium deficiency except for plasma magnesium decrease; these included renal calcinosis, soft tissue calcifications, and an increase in plasma inorganic phosphate and urea. Decreases in glomerular filtration rate and plasma alkaline phosphatase were also prevented. The site of action of fluoride may be on renal calcinosis because renal calcinosis is presumably a major determinant for the other magnesium deficiency defects in KK mice. The growth inhibition and alopecia caused by the low magnesium diet were also prevented by fluoride feeding. The mechanism, however, remains to be solved.

KEY WORDS: • magnesium deficiency • KK mice • renal calcinosis • plasma components

Manuscript received 5 August 1971.