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Effect of Excess L-Histidine Diet on Active Transport of L-Histidine by Isolated Rat Small Intestine

Laboratory of Nutritional Chemistry, Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Sakyo, Kyoto 606, Japan

Effects of protein deficiency and excessive administration of histidine on the active transport of L-histidine by the rat were investigated using everted segments of small intestine. Compared with a 20% casein diet, a 5% casein diet produced a significant increase in transport activity, and a 5% casein + 5% L-histidine diet produced an even greater increase. Responses to the diets varied in the different regions of the small intestine; the most significant increase was found in the middle portion when a 5% casein diet was fed, but in the upper portion when a 5% casein + 5% L-histidine diet was fed. Thinning of the intestinal wall, which accompanied the loss of body weight during the period of feeding nutritionally inadequate diets, did not account for the increased activity of the intestinal active transport.

KEY WORDS: • protein deficiency • histidine excess • intestinal active transport

Manuscript received 30 July 1971.