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Characterization of Vitamin K from Human Liver^{1 ,2}

Department of Biochemistry, University of Nebraska College of Medicine, Omaha, Nebraska 68105

Preparative purification of natural vitamin K from human liver was accomplished by extraction, chromatography on silicic acid, extraction with Claisen's alkali, and several additional chromatographic methods. Ultraviolet absorption and mass spectrometry of the purified samples supported the presence of phylloquinone, MK-7, MK-8, MK-9, MK-9(H₂), MK-9(H₄), MK-10, MK-10(H₂), MK-10(H₄), and MK-11. The principal vitamins were phylloquinone and MK-7.

KEY WORDS: • vitamin K • menaquinones • liver

¹ A preliminary report of the studies contained in this paper was presented at the meeting of the Federation of American Societies for Experimental Biology at Chicago, April, 1971.

² Supported in part by Grant AM 15152-01 from the National Institutes of Health.

Manuscript received 3 September 1971.