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Nickel Deprivation in Chicks¹

University of Connecticut, Colleges of Medicine and Agriculture, Newington and Storrs, Connecticut 06111

To investigate the effects of nickel deprivation, 12 chicks (group A) were grown in isolation from environmental nickel, and were fed a diet which contained 44 ppb of nickel. Twelve control chicks (group B) were treated similarly and were fed the same diet with added nickel (3.4 ppm Ni as NiCl₂). Nickel deprivation was produced in the chicks of group A, based upon the presence of diminished mean concentrations of nickel in serum and liver on day 30 (serum Ni = 1.6 ± 0.3 µg/liter in group A, versus 4.2 ± 0.4 µg/liter in group B, P < 0.001; hepatic Ni = 64 ± 6 µg/kg dry weight in group A, versus 82 ± 9 µg/kg dry weight in group B; P < 0.01). After 30 days, there were no significant differences between groups A and B in

(a) body weights,

(b) appearance of legs on physical and X-ray examinations,

(c) hematological parameters,

(d) concentrations of serum cholesterol, or

(e) histological appearance of organs and tissues by light microscopy.

KEY WORDS: • nickel • endoplasmic reticulum

¹ Supported by U. S. Atomic Energy Commission Grant AT (30-1)-4051 and U. S. Environmental Protection Agency Contract EHS-C-71-109.

² Department of Laboratory Medicine, University of Connecticut School of Medicine, P.O. Drawer B. Newington, Connecticut 06111.

³ Department of Animal Diseases, University of Connecticut College of Agriculture and Natural Resources, Storrs, Connecticut 06268.

Manuscript received 23 August 1971.