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Effect of Different Levels and Proportions of Methionine, Cystine, Choline, and Inorganic Sulfur on Growth and Body Composition of Young Rats^1,2,

Department of Foods and Nutrition, Purdue University, Lafayette, Indiana 47907

Quantities of methionine (M) and cystine (C) in diets fed to weanling rats were modified to provide four levels of total organic sulfur (S) between 0.150 and 0.075% of the diet in three ratios with respect to source of S, namely, 70M:30C, 50M:50C and 30M:70C. Both level of organic S and ratio between methionine and cystine significantly influenced food intake, weight gain, carcass nitrogen and concentration of hepatic choline and nitrogen, but only the ratio between the S-acids altered liver lipid. Interaction between level of organic S and ratio between methionine-S and cystine-S was significant for food intake, weight gain, weight of liver and concentration of hepatic choline and nitrogen. The 70M:30C ratio was superior to the 30M:70C ratio at all levels of total S whether or not choline was provided, but the 70M:30C ratio was superior to 50M:50C only in the absence of dietary choline. Therefore, the relative amount of each S-acid in the diet of the growing rat must be considered as well as the total quantity of organic S and the adequacy of dietary choline. Added inorganic S did not significantly influence any of the above parameters.

KEY WORDS: • methionine • cystine • choline • sulfur

¹ From Purdue University Agricultural Experiment Station and School of Home Economics, Department of Foods and Nutrition, Lafayette, Indiana 47907. Journal paper 4356. The data were taken from a thesis submitted by Martha H. Byington in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Purdue University; and the research was supported in part by a fellowship under the National Defense Education Act — Title IV.

² A preliminary report was presented at the Meeting of the Federation of American Societies for Experimental Biology in Atlantic City, N.J., April 1970. Byington, M., J. M. Howe and H. E. Clark 1970 Influence of cystine, choline and inorganic sulfate upon the utilization of methionine by the weanling rat. Federation Proc. 29: 427 (abstr.).

³ Present address: 2243 Harcourt Dr., Cleveland, Ohio 44106.

⁴ Reprint requests should be directed to this author.

Manuscript received 15 March 1971.