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Fetal Growth and Placental Permeability in Rabbits Fed Cholesterol¹

Graduate School of Nutrition and Section of Biochemistry and Molecular Biology, Division of Biological Sciences, Cornell University, Ithaca, New York 14850

Rabbits fed cholesterol before and during pregnancy showed a high fetal mortality. Decreasing the dose and duration of cholesterol feeding decreased this mortality. Successful insemination in cholesterol-fed does was less frequent than in control animals. Fetuses from cholesterol-fed does weighed significantly less than those from control does, but newborn young did not show a significant difference in birth weight. Placentas from cholesterol-fed does showed greatly increased concentrations of cholesterol, particularly in the esterified form. Placental transfer of ¹²¹I measured in vivo did not show significant differences as a result of cholesterol feeding.

KEY WORDS: • fetal growth • placental permeability • cholesterol • rabbit

¹ Supported in part by funds provided by Public Health Research Grant HE 10933 from the National Heart Institute, U. S. Public Health Service, and in part by funds provided through the State University of New York.

² Career Investigator of the American Heart Association.

Manuscript received 24 April 1972.