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Further Studies on Tibial Dyschondroplasia (Cartilage Abnormality) in Young Chicks¹

Departments of Poultry Science, Pennsylvania State University, University Park, Pennsylvania 16802 and Cornell University, Ithaca, New York 14850

Data are presented which suggest that tibial dyschondroplasia (abnormal cartilage formation) is the result of an inherited physiological defect the expression of which is under dietary influence. The importance of heredity is evidenced by the ability to develop, through family selection, high and low incidence strains. The occurrence of the abnormality in the high incidence or susceptible strain is easily altered through dietary manipulation. The nutritional factors involved have eluded identification. Corn and soybean meal are the best sources of activity although considerable amounts are required to produce significant reductions in incidence. Manipulations of the mineral mixture which result in changes in acid-base and/or cation-anion balance alter the incidence of the abnormality. However, changes in blood acid-base balance do not appear to be the primary factor involved in the occurrence of tibial dyschondroplasia.

KEY WORDS: • tibial dyschondroplasia • chicks • cartilage abnormality

¹ Supported in part by Public Health Service Grant no. AM 06850 from the National Institute of Arthritis and Metabolic Diseases. Authorized for publication on March 17, 1972 as journal series no. 4162 in the journal series of the Pennsylvania Agricultural Experiment Station.

Manuscript received 29 March 1972.

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