QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Forsyth, D. M. Articles by Krook, L. Search for Related Content PubMed PubMed Citation Articles by Forsyth, D. M. Articles by Krook, L.

Dietary Calcium and Fluoride Interactions in Swine: In Utero and Neonatal Effects^{1, 2,}

Department of Animal Science, New York State College of Agriculture and Life Sciences, and New York State College of Veterinary Medicine, Cornell University, Ithaca, New York 14850

Piglets at birth and at 4 weeks of age from successive litters and successive generations from dams fed diets containing low (0.5 and 0.4%) or high (1.2 and 1.0%) calcium and phosphorus levels, respectively, and 0, 30, 150, or 450 ppm additional fluoride were examined for physical and chemical changes in bone and for histologic changes in bone and soft tissues. In the bones of baby pigs at birth, there was no "generation build-up," nor an increase of fluoride concentration in the first versus the second litter. Increase in fluoride concentration was a linear function of the amount of fluoride in the diet of the sow, and was influenced by level of calcium-phosphorus in the diet. Increased dietary calcium-phosphorus level decreased fluoride accumulation in offspring at high fluoride levels, producing a calcium-phosphorus level x fluoride interaction in pigs both at birth and 4 weeks of age. Humerus density of pigs at birth was influenced nonlinearly by fluoride; intermediate fluoride levels decreased humerus density, but the highest level did not. Decreased length, width, volume and fresh weight of the humerus of baby pigs from sows fed additional fluoride indicated a depression of skeletal growth of fetuses due to fluoride; histologic fluorochrome techniques showed that this depression persisted in the 4-week-old pig. Neither level of calcium-phosphorus nor level of fluoride in the diet of the dam influenced calcium or phosphorus concentrations of the bone of offspring or caused any pathological changes in soft tissues examined.

KEY WORDS: • calcium • phosphorus • fluoride • progeny • swine

¹ Supported in part by National Institutes of Health Grant GM-1221 and by funds from the New York State College of Agriculture and Life Sciences.

² Data are from portions of a thesis submitted to Cornell University by Dale M. Forsyth in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

³ Present address: Department of Animal Sciences, Purdue University, Lafayette, Indiana 47907.

⁴ Department of Pathology, New York State Veterinary College, Cornell University, Ithaca, New York 14850.

Manuscript received 8 March 1972.