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Effect of Diet on Self-starvation in the Rat¹

Research and Psychology Services, Wood Veterans Administration Center and Departments of Pharmacology and Psychiatry, Medical College of Wisconsin, Milwaukee, Wisconsin 53193

Male rats housed in cages with activity wheels and fed laboratory diet for 1 hour per day increased their running activity without a proportionate rise in food intake, and most of them died within 1 week. Rats receiving a high fat diet under similar conditions consumed more calories and showed much less running activity; most of them survived the 1-week experimental period. Similar differences in running activity and survival were observed when the animals receiving the high fat diet were pair-fed with the rats fed laboratory diet. These results suggest that the high fat diet protected the animals against the self-starvation effect by reducing their running activity.

KEY WORDS: • diet • self-starvation

¹ Supported in part by Tops Club, Inc.; and the Obesity and Metabolic Research Program, Deaconess Hospital, Milwaukee, Wisconsin.

Manuscript received 23 June 1971.