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Effect of Various Restricted Dietary Regimens on the Growth, Health and Longevity of Albino Rats¹

The Procter and Gamble Company, Miami Valley Laboratories, Post Office Box 39175, Cincinnati, Ohio 45239

Ad libitum feeding, customarily used for nutritional and toxicological studies, usually leads to obesity and reduced longevity in long-term studies. This experiment was designed to compare the effects of various restricted regimens on the growth, mortality and several physiological parameters in rats in order to develop a regimen which would reduce obesity and mortality, yet maintain a realistic model. Male and female rats were fed a semipurified diet as follows: 1) ad libitum, 2) restricted to 80% of ad libitum intake throughout life, 3) same as 2 except restricted to 60%, 4) ad libitum 12 weeks, then restricted to 80%, 5) same as 4, except restricted to 60%, 6) restricted to 80% for 12 weeks, then ad libitum and 7) same as 6, except restricted to 60%. Regimens 2, 3, 4 and 5 reduced the ultimate size and mortality in both sexes. Rats in groups 3 and 5 had the lowest mortality, but were significantly different from group 1 in many parameters. Regimen 2 resulted in twice as many survivors and characteristics not significantly different from regimen 1 at 2 years. Rats in groups 6 and 7 had a mortality rate similar to group 1, but had more disturbed biological characteristics, such as smaller vital organs and increased levels of liver and body fat.

KEY WORDS: • dietary restriction • growth • longevity • obesity

¹ Presented in part at FASEB meeting, Atlantic City, N. J., 1970; Federation Proc. 29: Abstract 632, 1970.

Manuscript received 3 December 1971.

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