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Journal of Nutrition Vol. 102 No. 11 November 1972, pp. 1441-1451
Copyright © 1972 by American Society for Nutrition
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Effect of D-Alanine and D-Aspartic Acid on the Chick1

Kimiaki Maruyama, M. L. Sunde and A. E. Harper

Departments of Poultry Science, Nutritional Sciences and Biochemistry, University of Wisconsin, Madison, Wisconsin 53706

Some effects of feeding chicks D- or L-dispensable amino acids for 2 weeks in three types (practical, purified and amino acid) of complete diets have been studied. Growth was depressed significantly by 1.5% of D-alanine, but not by 2% of L-alanine or 2% of D-serine. When the amino acid diet contained 4.4% of other D-amino acids, 1.25% of D-alanine also caused growth depression. Two percent of D-aspartic acid depressed growth significantly, whereas 6% of L-aspartic acid did not. When D-aspartic acid was replaced by L-aspartic acid after 1 week, growth rate and feed consumption increased rapidly and approached values for control birds. Plasma aspartic acid concentration, which was high when D-aspartic acid was fed returned to near normal within 2 days. Plasma free aspartic acid concentration increased to 25-fold the normal value within 3 days when the D-aspartic acid was substituted for the L-form after 1 week. A high plasma free aspartic acid concentration was maintained in chicks fed 2% of D-aspartic acid. L-Aspartic acid at 3% in the diet did not elevate plasma aspartic acid concentration. High protein (35% and 50%) diets, amino acid supplements and additional vitamins all failed to overcome the growth-depressing effect of D-aspartic acid.

KEY WORDS: • D-alanine • D-aspartic acid • chick

1 Research supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison, and by the Experimental Station, Nutritional Foundation, New York, N. Y.

Manuscript received 3 March 1972.




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