QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Searcey, M. T. Articles by Arata, D. A. Search for Related Content PubMed PubMed Citation Articles by Searcey, M. T. Articles by Arata, D. A.

A Comparison of the Metabolism of Geometrical Isomers of ¹⁴C-⁹-Octadecenoic Acid in Threonine-imbalanced Rats^{1, 2,}

Department of Foods and Nutrition, Michigan State University, East Lansing, Michigan 48823

To explore the means by which dietary elaidic acid can limit liver lipid accumulation in threonine-imbalanced rats, ¹⁴C-elaidic acid was given to animals prefed threonine-imbalanced diets containing elaidinized olive oil. ¹⁴C-oleic acid-dosed animals fed untreated olive oil as the diet fat served as controls. Tissue radioactivity was assessed 4 and 8 hours after gavage. Elaidic acid was excreted via the urine at a slower rate than oleic acid; however, it initially was incorporated into liver phospholipids and low density lipoproteins to a much greater extent than oleic acid. When ¹⁴C-elaidic acid was given to animals prefed untreated olive oil, it was distributed in the same manner as in the animals prefed elaidinized olive oil.

KEY WORDS: • octadecenoic acid • elaidic acid • oleic acid • threonine imbalance

¹ Michigan Agricultural Experiment Station Journal Article no. 5550.

² Supported in part by Arthritis and Metabolic Diseases Division, National Institutes of Health, Grant no. 6093.

³ Present address: Department of Biochemistry, School of Medicine, St. Louis University, St. Louis, Missouri 63104.

⁴ Present address: Assistant Provost, Michigan State University, East Lansing, Michigan 48823.

Manuscript received 5 August 1971.