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Palmitic Acid as a Source of Endogenous Acetate and ß-Hydroxybutyrate in Fed and Fasted Ruminants^{1, 2,}

Department of Dairy Science, Ohio Agricultural Research and Development Center, Wooster, Ohio 44691

In order to ascertain the endogenous origin of acetate and ß-hydroxybutyric acid, specific radioactivities of plasma acetate, ß-hydroxybutyrate and palmitate were determined after infusion of 1-¹⁴C-palmitate into fed cows and fed or fasted sheep. Less than 2% of plasma acetate carbon and 5% of ß-hydroxybutyrate carbon were derived from palmitate in fed animals, whereas these values were increased to 16 and 29%, respectively, in fasted ruminants. The data support a role for ß-oxidation of long-chain fatty acids as a source of endogenous acetate and of ß-hydroxybutyrate in ruminants.

KEY WORDS: • palmitate oxidation • endogenous acetate • fasting • ruminants • ß-hydroxybutyrate

¹ Approved for publication as Journal Article no. 26–72 by the Associate Director of the Ohio Agricultural Research and Development Center, Wooster, Ohio 44691.

² Presented in part at AIN Annual Meeting, FASEB, Atlantic City, N. J., April 1970; Federation Proc. 29: 691 (abstr.).

Manuscript received 14 March 1972.