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Changes in the Activity of Acetyl CoA Carboxylase in the Intestinal Mucosa of the Rat During Development¹

Departments of Paediatrics and Obstetrics & Gynaecology, University of British Columbia, Vancouver, B. C.

Acetyl CoA carboxylase (EC 6.4.1.2) activity was determined in the mucosa of the small intestine of rats aged 1 day to 3 months. In the proximal third, activity increased tenfold between days 10 and 24 and about fivefold between day 24 and 3 months. The changes in the 2nd and 3rd were much smaller so that a proximo-distal gradient developed in adult animals. Feeding 16-day-old rats a fat-free diet for 5 days caused an eightfold increase in activity in all three portions of the small intestine. Feeding the same diet to 3-month-old rats doubled the activity in all three portions of the intestine but the already formed proximo-distal gradient remained unchanged.

KEY WORDS: • acetyl CoA carboxylase • development of rat intestinal mucosa

¹ Supported by Grants from M.R.C. (Canada) and the B.C. Heart Foundation.

² Supported by the B.C. Medical Research Foundation.

Manuscript received 27 March 1972.