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Journal of Nutrition Vol. 101 No. 9 September 1971, pp. 1177-1184
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Effect of Iron on Lipid Metabolism of Tetrahymena pyriformis1,2,

Yei-Mei Peng and C. E. Elson

Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706

Increased synthesis of phosphonic analogues of phospholipids was observed in Tetrahymena pyriformis grown in media supplemented with iron. These compounds imparted resistance to phospholipase C hydrolysis. Iron supplementation also increased microsomal {Delta}-6-desaturase activity resulting in synthesis of a {Delta}-6,9 isomer of linoleic acid. These findings are discussed in relation to the increased glyconeogenic capacity of iron-grown Tetrahymena.

1 Supported in part by U. S. Public Health Service Grant no. GM 14033 and the Wisconsin Agricultural Experiment Station Project 1555.

2 Approved for publication by the Director of the Research Division of the College of Agricultural and Life Sciences, University of Wisconsin.

Manuscript received 15 January 1971.




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