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Maintenance of Nitrogen Balance in a Young Woman by Substitution of -Ketoisovaleric Acid for Valine¹

Metabolism and Nutrition Unit, Instituto de Investigaciones Médicas, Facultad de Medicina and Department of Organic Chemistry, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, República Argentina

Negative nitrogen balance was induced in a young female by removing valine from a diet containing 10.3 g of nitrogen composed of glycine, diammonium citrate and the eight essential L-amino acids in the proportion present in egg protein. Addition of -ketoisovaleric acid decreased negative nitrogen balance and reverted it to equilibrium when an amount equivalent to three times that of valine was administered. Negative nitrogen balance returned when -keto acid supplement was withdrawn.

Manuscript received 16 February 1971.