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Utilization of 7-Chloro-8-methyl-flavin in the Rat and Its Specific Antiriboflavin Action in the Kidney^1,2,

Department of Biological Chemistry School of Medicine, The University of Maryland,⁴ Baltimore, Maryland 21201

Recovery from the visually observable signs of deficiency of the riboflavin-deficient rat during the administration of 7-chloro-8-methyl-flavin has been found to be due to utilization of the analogue by the rat. The analogue was also responsible for the animal's efficient utilization of food. The animal was unable to avoid the lethal effects of the analogue and the evidence suggests that this was due to the specific effect it had on the lowering of riboflavin concentration of the kidney and a concomitant rapid fall of the succinic acid dehydrogenase activity of the kidney. If the analogue-treated animal had free access to food, its food consumption was increased, it gained weight, and thereby diluted all of its tissue stores of riboflavin.

² Certain portions of this work were presented before The International Symposium on Antivitamins, Zürich-Feldbach, October 19–22, 1964.

³ To whom inquiries concerning this report should be sent.

⁴ Some of this work was done in the Department of Biochemistry, University of Nebraska College of Medicine.

Manuscript received 16 February 1971.