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Evidence for a Dual Role of Creatine in the Regulation of Kidney Transamidinase Activities in the Rat¹

Department of Biochemistry, College of Medical Sciences, University of Minnesota, Minneapolis, Minnesota 55455

Studies on the mechanism of the alteration of rat kidney transamidinase activities by dietary supplementation with nitrogen-containing compounds have been conducted. Glycine supplementation was without any effect on the low transamidinase activities ( 50% of the control values) of kidneys from rats fed diets supplemented individually with small amounts of creatine, guanidinoacetic acid, or arginine plus glycine. However, glycine supplementation did have an effect on the low transamidinase activities ( 20% of control values) of kidneys from rats fed diets supplemented individually with large amounts of creatine or guanidinoacetic acid. The enzyme activities were proportional to the amounts of glycine added to the creatine- or guanidinoacetic acid-supplemented diets; however, activities greater than 50% of the control values were not obtained as a result of glycine supplementation. Large amounts of creatine were found in the kidneys from rats fed the diets supplemented individually with creatine, guanidinoacetic acid, or arginine plus glycine; therefore, the alteration of enzyme activities by guanidinoacetic acid or arginine plus glycine is believed to be indirect via creatine. The data on the effect of glycine on the transamidinase activities of kidneys from rats fed diets containing varying amounts of creatine are interpreted to the effect that creatine has a dual role in the regulation of transamidinase activities.

Manuscript received 30 October 1970.

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