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Effect of Previous High Fat Diet on Body Protein Metabolism in Rats

Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Chikusa, Nagoya, Japan

When rats were fed a high fat diet followed by a high carbohydrate test diet, they excreted less urinary nitrogen than rats fed only a high carbohydrate diet. Concomitantly, activities of two hepatic amino acid-catabolizing enzymes, e.g., threonine dehydratase and arginase, were significantly decreased in rats fed a high fat diet followed by a high carbohydrate diet. The ratio of radioactivity recovered from injected ¹⁴C-amino acids, ¹⁴C-body protein/respiratory ¹⁴CO₂, indicates that the body protein metabolism in rats fed a high fat diet followed by a high carbohydrate test diet is shifted to the anticatabolic fashion as compared with rats fed constantly a high carbohydrate diet. The analytical results of blood glucose in rats fed a high carbohydrate test diet indicate that the utilization of glucose is much reduced by the previous feeding of a high fat diet compared with the previous feeding of a high carbohydrate diet. It is inferred that a marked rise of blood glucose in fat-fed rats responding to the feeding of a high carbohydrate test diet may result in an increased secretion of insulin, which is known to exhibit an anticatabolic effect on the body protein metabolism in the animal.