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Evidence for Increased Constitutiveness of NADP-linked Dehydrogenases in the Starved-refed Rat

Human Nutrition Research Division, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland 20705

Rats were subjected to successive periods of 2 days' starvation and 2 days' refeeding. Maximum levels of glucose-6-phosphate and malic dehydrogenases were reached during the third starve-refeed cycle and did not increase further during a fourth cycle. Administration of 8-azaguanine only during the last 2 days of refeeding prevented the enzyme overshoot in every case, but the enzyme levels reached in these rats increased with successive cycles of starvation. This was interpreted as evidence for increased accumulation of specific RNA required for the synthesis of these enzymes. This phenomenon was termed increased constitutiveness. Total liver lipid levels reached a maximum after one starve-refeed cycle and did not increase further during subsequent cycles. This was interpreted as due possibly to a compensatory effect on lipid transport from the liver. A theory is presented which links a tendency toward obesity with increased enzyme constitutiveness and internal loss of control.

Manuscript received 12 November 1970.