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Journal of Nutrition Vol. 101 No. 7 July 1971, pp. 831-838
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Dietary and Hormonal Effects on Extended Lactation and Lipid Metabolism in Rats1

R. S. Emery, J. D. Benson2 and H. A. Tucker

Dairy Department, Michigan State University, East Lansing, Michigan 48823

To study the influence of extra dietary protein and fat on prolonged lactation and the mechanism whereby glucocorticoid maintains lactation, litters were replaced at days 16 and 24 of lactation with 8-day old foster litters. Control (22% protein), 41% protein and 50% fat diets, were fed throughout lactation. Litter weight gains were greater with the normal diet between days 8 and 16 of lactation but the high fat diet supported 59% greater gains than the control diet between days 16 and 32 of lactation. Fat deposition accounted for about 75% of this extra litter weight gain and the caloric efficiency of the 50% fat diet during prolonged lactation was 1.5 times greater than with the control diet. Daily subcutaneous injections of 50 µg 9-fluoropredisolone acetate into the mothers between days 16 and 32 of lactation increased litter weight gains by 21 and 52% with the three rations. This increased litter weight could be attributed largely to increased loss of body substance from the mothers. Both the high fat diet and exogenous glucocorticoid helped maintain mammary size, protein content, protein synthesizing activity and glyceride synthesizing activity although these effects were not uniformly significant. It is concluded that a high fat diet and exogenous glucocorticoid augment prolonged lactation in a largely independent and additive manner.

1 Supported in part by U. S. Public Health Service Grant AM 13177; published with the approval of the Director of the Michigan Agricultural Experiment Station as Journal Article No. 5281.

2 Present address: Letterman Army Institute of Research, San Francisco, California.

Manuscript received 20 November 1970.




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