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In vitro and in vivo Restoration of Hepatic Lipogenesis in Fasted Chicks¹

Laboratory of Nutritional Biochemistry, Department of Animal Science, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801

The effectiveness, in vitro and in vivo, of glucose or fructose and in vitro of glycerol in restoring hepatic fatty acid synthesis in chicks subjected to short periods of fast was studied. Chicks fasted for 2 to 4 hours had a capacity for hepatic fatty acid synthesis which was less than 20% of that observed in fed chicks. The impaired lipogenesis could be at least partially restored by the intravenous injection of glucose or fructose. However, the reduced rate of in vitro fatty acid synthesis was not stimulated to normal by the addition of glucose, fructose, or glycerol to the medium in which liver slices from fasted chicks were incubated. The increased level of circulating free fatty acids in fasted chicks was returned to normal or below normal values by the intravenous administration of glucose or fructose. The stimulation of hepatic lipogenesis in vivo by glucose administration to fasted chicks was preceded by a decline in the level of plasma free fatty acids. The implication of these observations with regard to the mechanisms regulating hepatic lipogenesis in the chick is discussed.

² Present address: Department of Chemistry, Utah State University, Logan, Utah 84321.

Manuscript received 23 November 1970.