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Biochemical Factors Involved in the Anorexia of Thiamin Deficiency in Rats^1,2,3,

Departments of Food Science and Nutrition and Chemistry, Brigham Young University, Provo, Utah 84601

Rats were made deficient in thiamin diphosphate by thiamin deprivation and by treatment with oxythiamin or pyrithiamin, and the pyruvate dehydrogenase and transketolase activities of the intestinal mucosa were measured at various stages of the development of the deficiency. Transketolase activity decreased sooner and more markedly than did pyruvate dehydrogenase activity, and the decrease in transketolase activity correlated most closely with the development of anorexia symptoms. It is suggested that the decrease in transketolase activity may be one of the biochemical lesions related to the development of anorexia, although other possibilities are not excluded by the data presented.

² Supported by Public Health Service Research Grant no. AM02448 from the National Institute of Arthritis and Metabolic Diseases.

³ Presented at the Pacific Slope Biochemical Conference, San Diego, June, 1970.

⁴ Present address: Biosurgical Laboratory, Surgery Department, University of Utah, Salt Lake City.

Manuscript received 12 November 1970.