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Effects of Dietary Modifications on Cholesterol-induced Anemia in Guinea Pigs^1,2,

Department of Nutritional Sciences, University of California, Berkeley, California 94720

This series of experiments was designed to test the hypothesis that the hemolytic anemia, the pathological changes in liver and other organs and the changes in plasma and tissue lipids observed in cholesterol-fed guinea pigs are specific effects of cholesterol. The levels of different dietary components were varied, and their effects on growth, incidence of anemia and changes of tissue lipids were measured. The dietary components chosen for study were those known either to affect lipid accumulation in liver, intestinal absorption or metabolism of cholesterol or to be involved in the stability of RBC in vitro or in vivo. The results showed that increased levels of dietary protein, choline, vitamin C and vitamin E had no protective effects against the cholesterol-induced changes. These findings indicate that the nutrients studied are not involved in the effects of cholesterol in the guinea pig. The effects of vitamin E deficiency in cholesterolfed guinea pigs were studied in some detail.

² Portions of this work have been presented at the Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, April 1970.

Manuscript received 15 June 1970.