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Lack of Mobilization of Bone and Liver Zinc under Teratogenic Conditions of Zinc Deficiency in Rats¹

Department of Nutrition, University of California, Davis, California 95616

The effect of pregnancy on the zinc content of maternal bone and liver was determined in rats fed either a zinc-deficient or a zinc-supplemented purified diet. Although the zinc content of fetuses from deficient females was lower than that of fetuses from zinc-supplemented controls, the zinc content of maternal liver and bone was not significantly lower at term than that of nonpregnant rats fed the same diet for 21 days. These results substantiate the hypothesis that even in the presence of teratogenic zinc deficiency in the fetus, female rats fed a zinc-deficient diet during pregnancy cannot mobilize zinc from body tissues in amounts sufficient to supply the needs of normal fetal development.

Manuscript received 17 December 1970.

This article has been cited by other articles:

				K. Simmer and R.P.H. Thompson Zinc And The Fetus Perspectives in Public Health, October 1, 1986; 106(5): 166 - 168. [PDF]

				H. Swenerton and L. S. Hurley Teratogenic Effects of a Chelating Agent and Their Prevention by Zinc Science, July 2, 1971; 173(3991): 62 - 64. [Abstract] [PDF]