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Journal of Nutrition Vol. 101 No. 4 April 1971, pp. 533-538
Copyright © 1971 by American Society for Nutrition
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Ethanol Feeding and Choline Deficiency as Influences on Hepatic Choline Uptake1

A. J. Barak, D. J. Tuma and H. C. Beckenhauer

Medical Research Service, Veterans Administration Hospital, 4101 Woolworth Avenue, Omaha, Nebraska 68105

This study shows that rats fed a choline-deficient diet for 5 days have livers which under perfusion have an increased ability to take up exogenous choline. Choline-deficient animals fed the diet for 21 days have livers that show normal choline uptake. Animals fed ethanol for a 24-day period were shown to have livers which on perfusion took up higher quantities of choline than control livers. The results of the ethanol-feeding experiment are explained on the basis of the findings of other workers that ethanol increases the requirement for choline in the liver.

1 This work was supported in part by a grant-in-aid from the Licensed Beverage Industries, Inc., New York, N. Y.

Manuscript received 14 September 1970.




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