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Placental Transfer of Fluoride and Tin in Rats Given Various Fluoride and Tin Salts

Department of Nutritional Research, Mead Johnson Research Center, Evansville, Indiana 47721

Fluoride passes the placenta in limited amounts and may bestow caries resistance upon developing teeth. In a recent report, offspring of rats fed a diet containing sodium pentafluorostannite during gestation were found to have reduced caries incidence compared to offspring of rats fed sodium fluoride. In order to determine whether this observation was related to increased placental transfer of fluoride, pregnant rats were fed diets containing 50, 100, and 200 ppm fluoride or equivalent, from the following salts: sodium pentafluorostannite, sodium pentachlorostannite, sodium fluoride, stannous fluoride, or a mixture of sodium and stannous fluorides. On day 20 of gestation, fetuses and placentas were obtained for analyses. The average fluoride levels of the fetuses from rats fed 50, 100, and 200 ppm fluoride diets ranged from 0.6 to 0.9 ppm, 1.1 to 2.0 ppm, and 3.0 to 4.0 ppm fluoride, respectively. None of the salts appeared to have a significantly different efficiency of placental transfer of fluoride. Fetal tin values were elevated when the maternal diet contained tin salts, but without apparent relation to dietary tin level.

Manuscript received 21 September 1970.