Journal of Nutrition

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Journal of Nutrition Vol. 101 No. 4 April 1971, pp. 515-524
Copyright © 1971 by American Society for Nutrition
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Steroids Influencing the Toxicity of L-Tyrosine1

Hans Selye

Institute de médecine et de chirurgie expérimentales, Université de Montréal, Montreal, Canada

In rats, the typical features of dietary tyrosine intoxication, including inflammatory changes in the eyes, pancreas, paws and snout, can be prevented not only by glucocorticoids (triamcinolone, prednisolone) but also by typical catatoxic steroids devoid of glucocorticoid potency. Among the latter PCN (pregnenolone-16{alpha}-carbonitrile), ethylestrenol, compound CS-1 (manufacturer's code number SC-11927), spironolactone, norbolethone and progesterone are efficacious. Estradiol has no glucocorticoid effect and is also devoid of catatoxic potency against other toxicants, yet, it likewise offers some protection against tyrosine intoxication. On the other hand, oxandrolone, desoxycorticosterone, hydroxydione and cholesterol are ineffective in this respect. Phenobarbital, a nonsteroidal catatoxic enzyme inducer, offers excellent protection against tyrosine intoxication, whereas thyroxine aggravates it.

1 Supported by the Ministère de la Santé, Québec, the Medical Research Council of Canada (Block Term Grant MT-1829) and the Quebec Heart Foundation, Montreal. Undertaken as a special project of the Council for Tobacco Research, U.S.A. and the Canadian Tobacco Industry.

Manuscript received 10 August 1970.




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