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Protein Loss from the Normal Human Small Intestinal Mucosa¹

Gastrointestinal Laboratory, The Department of Medicine, University of the West Indies, Mona, Jamaica, West Indies

Protein loss from the small intestinal mucosa was measured in 12 subjects by means of a washing technique. The method effectively prevented contamination of the segment under study with the protein- and enzyme-rich digestive secretions from the stomach, biliary tree and pancreas. In 12 subjects the loss of protein from a 5-cm segment of duodenal mucosa was 2.1 mg per minute or 3.0 g per 24 hours. This rate of loss was very high and for the entire small intestine suggested a loss of tens of grams per 24 hours.

² Present address: Division of Gastroenterology, Hotel Dieu Hospital, Kingston, ontario, Canada.

Manuscript received 21 October 1970.