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Utilization of Fat and Glycerol for Glycogenesis by the Neonatal Rat¹

Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305

Hepatic glycogenesis from fat and glycerol has been studied in the fasted rat during development. Administration of either olive oil or glycerol resulted in marked hepatic glycogenesis in 5- to 10-day-old animals; this response was diminished in weaned rats and was almost absent in animals less than 48 hours old. The incorporation of ¹⁴C-glycerol into hepatic glycogen was greater in 9-day-old neonatal rats than in weaned animals. Although glycerol kinase activity was low in liver of animals less than 48 hours of age, these young animals readily converted ¹⁴C-glycerol into ¹⁴CO₂. Our results indicate that glycerol is utilized via different pathways depending on the age of the animal. Hepatic glycogenesis, following fat administration, in the 5- to 10-day-old rat can be explained on the basis of increased utilization of triglyceride-glycerol for glyconeogenesis during this period of neonatal life.

Manuscript received 18 September 1970.