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Further Studies on the Partial Lipotropic Effect of Dextrin in Choline-deficient Rats¹

Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

Choline-deficient rats fed dextrin as the major dietary carbohydrate accumulated less hepatic triglyceride than those fed sucrose. This effect could not be accounted for by a pseudolipotropic effect of dextrin since the rats fed dextrin grew as well as those fed sucrose. Further, increasing the nonnutritive bulk of the sucrose diets did not reduce the liver fat. Rats fed other simple sugars, viz. glucose, fructose and maltose also accumulated more fat than the dextrin-fed group. Increasing the fat content of the diets to 30% did not eliminate the differences in hepatic triglycerides between the sucrose- and dextrin-fed groups, although the activities of lipogenic enzymes were similar in the two groups. Synchronization of feeding schedules also had no effect. Therefore, a hyperlipogenic effect of sucrose cannot be responsible for the increase in choline requirement in these rats. Supplementation of the diets with neomycin sulfate and sulfaguanidine did not abolish the differences between the sucrose- and dextrin-fed rats. A partially protective role of the intestinal bacterial flora in the dextrin-fed rats against the fatty liver of choline deficiency can still not be ruled out.

Manuscript received 26 June 1970.